卵泡迁移对T细胞分化的影响。
The influence of follicular migration on T-cell differentiation.
作者信息
Smith Karen M, Brewer James M, Mowat Allan Mci, Ron Yacov, Garside Paul
机构信息
Division of Immunology, Infection and Inflammation, Western Infirmary, University of Glasgow, Glasgow G11 6NT, Scotland, UK.
出版信息
Immunology. 2004 Mar;111(3):248-51. doi: 10.1111/j.1365-2567.2004.01813.x.
Abstract
The sequence of events that leads to the development of a T-dependent B-cell response has been studied for many years and much attention has focused on the importance of these interactions for the B cell and the antibody response. While a role for B cells in T-cell memory has been demonstrated, the cellular and molecular mechanisms underlying this are unclear and the importance for T cells to migrate into follicles and interact with B cells has received relatively little attention. These interactions between T and B lymphocytes are facilitated by a co-ordinated series of migration events within lymph nodes and here we propose that this migration and these events are essential for the terminal differentiation of all CD4+ T cells and without it tolerance may result.
摘要
导致T细胞依赖性B细胞应答发生的一系列事件已被研究多年，许多注意力都集中在这些相互作用对B细胞和抗体应答的重要性上。虽然已经证明B细胞在T细胞记忆中发挥作用，但其潜在的细胞和分子机制尚不清楚，并且T细胞迁移到滤泡中并与B细胞相互作用的重要性相对较少受到关注。T淋巴细胞和B淋巴细胞之间的这些相互作用是由淋巴结内一系列协调的迁移事件促成的，在此我们提出，这种迁移和这些事件对于所有CD4+T细胞的终末分化至关重要，没有它可能会导致耐受性。
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