堪察加景天的抗炎活性。

Anti-inflammatory activity of Sedum kamtschaticum.

作者信息

Kim Dong Wook, Son Kun Ho, Chang Hyeun Wook, Bae KiHwan, Kang Sam Sik, Kim Hyun Pyo

机构信息

College of Pharmacy, Kangwon National University, Chunchon 200-701, South Korea.

出版信息

J Ethnopharmacol. 2004 Feb;90(2-3):409-14. doi: 10.1016/j.jep.2003.11.005.

DOI:10.1016/j.jep.2003.11.005

PMID:15013209

Abstract

Sedum kamtschaticum Fischer (Crassulaceae) has been used as a folk medicine in North-East Asia for treating inflammatory disorders. The present investigation was carried out to establish in vivo anti-inflammatory activity and cyclooxygenase-2 modulating activity of this plant material. The methanol extract of Sedum kamtschaticum significantly inhibited mouse croton oil-induced ear edema (24-47% inhibition at 50-400 mg/kg) and rat paw edema (24-30% inhibition at 400-800 mg/kg) by oral administration. Prednisolone (10 mg/kg) showed 54 and 36% inhibition in the same animal models, respectively. Sedum kamtschaticum also showed significant inhibitory activity against mouse ear edema induced by multiple treatment of phorbol ester for 3 days. In addition, Sedum kamtschaticum exhibited potent analgesic activity against mouse acetic acid-induced writhing (IC50=125 mg/kg), while aspirin (200 mg/kg) showed 57% inhibition. Using lipopolysaccharide-treated RAW 264.7 cells, down-regulation of cyclooxygenase-2 expression was found to be one of the cellular action mechanisms of anti-inflammation by Sedum kamtschaticum.

摘要

堪察加景天（景天科）在东北亚地区一直被用作治疗炎症性疾病的民间药物。本研究旨在确定这种植物材料的体内抗炎活性和环氧合酶 - 2调节活性。通过口服给予，堪察加景天的甲醇提取物显著抑制小鼠巴豆油诱导的耳肿胀（在50 - 400 mg/kg时抑制率为24 - 47%）和大鼠足肿胀（在400 - 800 mg/kg时抑制率为24 - 30%）。泼尼松龙（10 mg/kg）在相同动物模型中分别显示出54%和36%的抑制率。堪察加景天对佛波酯多次处理3天诱导的小鼠耳肿胀也显示出显著的抑制活性。此外，堪察加景天对小鼠醋酸诱导的扭体表现出强效镇痛活性（IC50 = 125 mg/kg），而阿司匹林（200 mg/kg）显示出57%的抑制率。使用脂多糖处理的RAW 264.7细胞，发现环氧合酶 - 2表达的下调是堪察加景天抗炎的细胞作用机制之一。