The synthesis of a novel thio-linked disaccharide of chondroitin as a potential inhibitor of polysaccharide lyases.
作者信息
Rye Carl S, Withers Stephen G
机构信息
Department of Chemistry, 2036 Main Mall, University of British Columbia, Vancouver, BC, Canada V6T 1Z1.
出版信息
Carbohydr Res. 2004 Feb 25;339(3):699-703. doi: 10.1016/j.carres.2003.12.011.
PMID:15013408
Abstract
A thio-linked disaccharide based on the structure of the glycosaminoglycan chondroitin was synthesized as a potential inhibitor of chondroitin AC lyase from Flavobacterium heparinum for structural analysis of the active site. Instead it was found to be a slow substrate, thereby demonstrating that lyases, in contrast to glycosidases, can cleave thioglycoside links between sugars.
摘要
Zotero 插件