May Flavia S, Chen Q Cece, Gilbertson Mark W, Shenton Martha E, Pitman Roger K
Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Biol Psychiatry. 2004 Mar 15;55(6):656-8. doi: 10.1016/j.biopsych.2003.09.018.
Abnormally large cavum septum pellucidum has been reported in posttraumatic stress disorder; however, the origin of this association is uncertain.
We utilized magnetic resonance imaging to measure cavum septum pellucidum in pairs of identical twins discordant for combat exposure in Vietnam.
Presence of abnormal cavum septum pellucidum was significantly correlated between exposed and unexposed twins, indicating that it is partially determined by heredity and/or shared environment. There was a greater proportion of cavum septum pellucidum in combat-exposed twins with posttraumatic stress disorder and their noncombat-exposed co-twins.
The presence of abnormally large cavum septum pellucidum is a familial vulnerability factor for posttraumatic stress disorder.
创伤后应激障碍患者中曾有报道出现异常增大的透明隔腔;然而,这种关联的起源尚不确定。
我们利用磁共振成像技术对在越南经历过战斗的同卵双胞胎进行测量,其中一对双胞胎中有一人经历过战斗,另一人未经历过战斗。
经历战斗的双胞胎和未经历战斗的双胞胎中,异常透明隔腔的出现存在显著相关性,这表明它部分由遗传和/或共同环境决定。在患有创伤后应激障碍且经历过战斗的双胞胎及其未经历战斗的同卵双胞胎中,透明隔腔的比例更高。
异常增大的透明隔腔的存在是创伤后应激障碍的一个家族易感性因素。