Unit on Affective Cognitive Neuroscience, National Institute of Mental Health, NIH, Bethesda, MD, USA.
J Child Psychol Psychiatry. 2013 May;54(5):575-81. doi: 10.1111/j.1469-7610.2012.02603.x. Epub 2012 Aug 31.
The presence of a large cavum septum pellucidum (CSP) has been previously associated with antisocial behavior/psychopathic traits in an adult community sample.
The current study investigated the relationship between a large CSP and symptom severity in disruptive behavior disorders (DBD; conduct disorder and oppositional defiant disorder).
Structural MRI scans of youth with DBDs (N = 32) and healthy comparison youth (N = 27) were examined for the presence of a large CSP and if this was related to symptom severity.
Replicating previous results, a large CSP was associated with DBD diagnosis, proactive aggression, and level of psychopathic traits in youth. However, the presence of a large CSP was unrelated to aggression or psychopathic traits within the DBD sample.
Early brain mal-development may increase the risk of a DBD diagnosis, but does not mark a particularly severe form of DBD within patients receiving these diagnoses.
先前的研究表明,在成年人群样本中,存在较大的透明隔腔(CSP)与反社会行为/精神病特质有关。
本研究旨在调查较大的 CSP 与破坏性行为障碍(DBD;品行障碍和对立违抗性障碍)的症状严重程度之间的关系。
对患有 DBD 的青年(N=32)和健康对照组青年(N=27)的结构 MRI 扫描进行检查,以确定是否存在较大的 CSP,以及这种情况是否与症状严重程度有关。
复制了先前的研究结果,较大的 CSP 与 DBD 诊断、主动攻击行为以及青少年的精神病特质水平有关。然而,在 DBD 样本中,较大的 CSP 与攻击行为或精神病特质无关。
早期大脑发育不良可能会增加 DBD 诊断的风险,但对于接受这些诊断的患者来说,并不标志着 DBD 是一种特别严重的形式。