Fukuzako T, Fukuzako H, Kodama S, Hashiguchi T, Takigawa M
Department of Neuropsychiatry, Faculty of Medicine, Kagoshima University, Japan.
Psychiatry Clin Neurosci. 1996 Jun;50(3):125-8. doi: 10.1111/j.1440-1819.1996.tb01675.x.
In order to determine if cavum septum pellucidum (CSP) is more prevalent in schizophrenic patients, we studied 72 Japanese patients who fulfilled the DSM-III-R criteria for schizophrenia and 41 normal controls. Sagittal, 1 mm thick magnetic resonance imaging slices of the entire cranium were obtained using a gradient-echo pulse sequence, and coronal and axial images were reconstructed for assessment. A CSP was observed in 34 patients (47.2%) and in 16 controls (38.0%). Although the CSP appeared to be more prevalent in schizophrenic patients, this difference was not statistically significant. However, schizophrenic patients with a history of long-term institutionalization had a higher incidence of CSP compared with patients who had not been admitted to hospital for more than 3 years (68.2 vs 38.0%). These results suggest that the CSP may be a pathophysiology that characterizes schizophrenic patients with poor prognoses.
为了确定透明隔腔（CSP）在精神分裂症患者中是否更为普遍，我们研究了72名符合DSM-III-R精神分裂症标准的日本患者和41名正常对照者。使用梯度回波脉冲序列获取整个颅骨的矢状面、1毫米厚的磁共振成像切片，并重建冠状面和轴位图像进行评估。在34名患者（47.2%）和16名对照者（38.0%）中观察到透明隔腔。虽然透明隔腔在精神分裂症患者中似乎更为普遍，但这种差异无统计学意义。然而，有长期住院史的精神分裂症患者与未住院超过3年的患者相比，透明隔腔的发生率更高（68.2%对38.0%）。这些结果表明，透明隔腔可能是预后不良的精神分裂症患者的一种病理生理学特征。
