选择性5-羟色胺再摄取抑制剂类抗抑郁药物：不良反应与耐受性
SSRI Antidepressant Medications: Adverse Effects and Tolerability.
作者信息
Ferguson James M.
机构信息
University of Utah, School of Medicine, Pharmacology Research Clinic, Salt Lake City.
出版信息
Prim Care Companion J Clin Psychiatry. 2001 Feb;3(1):22-27. doi: 10.4088/pcc.v03n0105.
Abstract
Side effects of antidepressants can be predicted by receptor selectivity and site of action. Although the selective serotonin reuptake inhibitors (SSRIs) have better overall safety and tolerability than older antidepressants, broad-based experience with SSRIs has shown the frequency and type of side effects to be increased relative to clinical trial data. The author explores the reasons for the different profiles and discusses adverse effects, especially sexual dysfunction, weight gain, and sleep disturbance, the most troubling adverse events seen during long-term SSRI therapy. The informed management of these side effects by primary care practitioners supports successful treatment of depression.
摘要
抗抑郁药的副作用可通过受体选择性和作用部位来预测。尽管选择性5-羟色胺再摄取抑制剂（SSRI）总体安全性和耐受性优于旧的抗抑郁药，但基于广泛经验的SSRI研究表明，相对于临床试验数据，其副作用的频率和类型有所增加。作者探讨了不同情况的原因，并讨论了不良反应，尤其是性功能障碍、体重增加和睡眠障碍，这些是长期使用SSRI治疗期间最令人困扰的不良事件。初级保健医生对这些副作用的明智管理有助于抑郁症的成功治疗。
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