Xu Xiao-hong
Academy of Life and Environment Science, Zhejiang Normal University, Jinhua 321004, Zhejiang, China.
Zhongguo Zhong Yao Za Zhi. 2003 Jan;28(1):66-9.
To study the effect of puerarin on fatty superoxide of aged mice induced by D-galactose.
The aged mice were induced by s.c. 0.12 g.kg-1 D-galactose for 6 weeks. Meanwhile, they were treated with three doses of puerarin once a day for 6 weeks. Then the spontaneous behavior was tested in the aged mice using open field at the next day after the last treatment. And the activity of SOD, the contents of MDA and lipofuscin in brain, liver, and serum were measured with Ultravioletray spectrometer and Fluorospectrophometer analysis system.
Compared with the D-galactose control group, puerarin of 50 mg.kg-1 and 100 mg.kg-1 puerarin significantly increased the spontaneous behavior, remarkably promoted the activity of SOD of brain, liver, and serum in the aged mice, and significantly decreased the contents of MDA and lipofuscin.
Puerarin can improve the activity of antioxidase of the modelling aged-mice induced by D-galactose.
研究葛根素对D-半乳糖致衰老小鼠脂肪超氧化物的影响。
将老年小鼠皮下注射0.12 g·kg-1 D-半乳糖诱导6周。同时，每天用三个剂量的葛根素处理6周。在最后一次处理后的第二天，使用旷场试验检测老年小鼠的自发行为。并用紫外可见分光光度计和荧光分光光度计分析系统测量脑、肝和血清中SOD的活性、MDA和脂褐素的含量。
与D-半乳糖对照组相比，50 mg·kg-1和100 mg·kg-1葛根素显著增加了老年小鼠的自发行为，显著促进了脑、肝和血清中SOD的活性，并显著降低了MDA和脂褐素的含量。
葛根素可提高D-半乳糖诱导的衰老模型小鼠抗氧化酶的活性。
