Gharbi Najoua, Mornagui Bessem, El-Fazaâ Saloua, Kamoun Abdelaziz, Gharib Claude
Laboratoire de physiologie animale, département de biologie, faculté des sciences de Tunis El-Manar, campus universitaire, 1060 Tunis, Tunisie.
C R Biol. 2004 Jan;327(1):12-20. doi: 10.1016/j.crvi.2003.11.003.
Effect of dehydration on nitric oxide, corticotropic and vasopressinergic axis in rat. The purpose of our work is to study, in the male 'Wistar' rat, the effects of a chronic dehydration, by deprivation of water for three days out of four, during four repeated cycles, on the evolution of certain blood variables, on the activities of both corticotropic and vasopressinergic axis and on the synthesis of nitric oxide. The chronic dehydration causes a considerable reduction of the body weight, an activation of the vasopressinergic axis and an increase in the circulating rates of the nitrates/nitrites, which represent the final metabolites of the reaction of oxidation of nitric oxide. The pituitary-adrenal axis is not statistically affected by the chronic dehydration. This seems to be in favour of a possible adaptation of corticotropic axis to chronic water deprivation. The activation of synthesis of nitric oxide shows its implication in the regulation of the water balance and its buffer effect on vasoconstriction and hypertension induced by water stress.
脱水对大鼠一氧化氮、促肾上腺皮质激素和血管加压素轴的影响。我们研究的目的是，在雄性“Wistar”大鼠中，通过每四天中有三天剥夺水分，进行四个重复周期，来研究慢性脱水对某些血液变量的变化、促肾上腺皮质激素和血管加压素轴的活性以及一氧化氮合成的影响。慢性脱水导致体重显著减轻、血管加压素轴激活以及硝酸盐/亚硝酸盐循环率增加，硝酸盐/亚硝酸盐代表一氧化氮氧化反应的最终代谢产物。慢性脱水对垂体-肾上腺轴没有统计学影响。这似乎有利于促肾上腺皮质激素轴对慢性缺水的可能适应。一氧化氮合成的激活表明其在水平衡调节中的作用及其对水应激诱导的血管收缩和高血压的缓冲作用。
