Ophir Ella, Oettinger Moshe, Nisimov Jakov, Hirsch Yael, Fait Vladimir, Dourleshter Grigory, Shnaider Oleg, Snitkovsky Tamara, Bornstein Jakov
Department of Obstetrics and Gynecology, Western Galilee Hospital, PO Box 21, Nahariya 22100, Israel.
Am J Perinatol. 2004 Jan;21(1):35-40. doi: 10.1055/s-2004-820508.
Umbilical plasma levels of lipoproteins-cholesterol were measured in 480 normal newborns delivered by spontaneous vaginal delivery at 39 to 40 weeks of gestation. Plasma concentrations of lipids were related to fetal weight, abdominal and head circumference, and ponderal index at birth. Plasma concentration of low-density lipoprotein cholesterol (LDL-C) correlated negatively with abdominal circumference (AC), birth weight, and head circumference of newborns (p < 0.021, p < 0.023, p < 0.044, respectively). The baby with the smallest AC had the highest plasma concentration of LDL-C (p < 0.015). In the 165 neonates with ponderal index < 10th percentile, LDL-C was substantially elevated (p < 0.018). These findings suggest that disproportionate size at birth is associated with altered lipid metabolism. These abnormalities, if they persist, might lead to metabolic diseases in adulthood.
对480例孕39至40周经阴道自然分娩的正常新生儿测定了脐血脂蛋白胆固醇水平。血脂浓度与出生时胎儿体重、腹围和头围以及 ponderal 指数相关。新生儿低密度脂蛋白胆固醇（LDL-C）血浆浓度与腹围（AC）、出生体重和头围呈负相关（分别为p < 0.021、p < 0.023、p < 0.044）。AC最小的婴儿LDL-C血浆浓度最高（p < 0.015）。在165例ponderal指数低于第10百分位数的新生儿中，LDL-C显著升高（p < 0.018）。这些发现表明出生时大小比例失调与脂质代谢改变有关。如果这些异常持续存在，可能会导致成年期的代谢疾病。
