Nayak Chandrika D, Agarwal Vaibhav, Nayak Dinesh M
Department of Biochemistry, Melaka Manipal Medical College (Manipal Campus), Manipal University, Udupi, Manipal, 576104 Karnataka India.
Kasturba Medical College, Manipal University, Manipal, 576104 Karnataka India.
Indian J Clin Biochem. 2013 Apr;28(2):152-7. doi: 10.1007/s12291-012-0252-5. Epub 2012 Aug 28.
Fetus with intrauterine stress may exhibit programmed changes that can alter its metabolism and bear severe risk for diseases in adult life. The current study was designed to assess the correlation between cord blood lipid profile with the anthropometric data in neonates.
146 newborn babies born at Dr. T M A Pai Hospital, Udupi were screened and their birth weight, length, head circumference and abdominal circumference were noted at birth. Umbilical cord blood samples were analyzed for total cholesterol, triglycerides (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL). Infants were also grouped further based on gestational age (GA) and sex-adjusted birth weight percentiles into three groups i.e. Small for gestational age (SGA), Appropriate for gestational age (AGA) and Large for gestational age (LGA) for comparison of their lipid profiles. Inclusion criteria were normal fetal heart rate at birth and an APGAR score >7. Statistical significance of relation between lipid profile and anthropometry was done using ANOVA and Pearson correlation coefficient.
Triglycerides were significantly higher in babies with higher ponderal index (PI) than those with lower PI (P = 0.011). The TG level of SGA babies were significantly higher as compared to AGA group (P = 0.001). The LDL levels in neonates with higher abdominal circumference were significantly lower than those with lower AC (P = 0.019). Mean HDL levels were higher in neonates with larger AC, but not statistically significant. Maternal BMI had no influence on neonates' lipid profile.
Abnormal intrauterine milieu created by maternal changes during gestation may bear a profound impact on lipid metabolism in neonates, which may account for their differences in lipid profile and anthropometry at birth.
处于宫内应激状态的胎儿可能会出现程序性变化，从而改变其新陈代谢，并在成年后患疾病的风险增加。本研究旨在评估新生儿脐血脂谱与人体测量数据之间的相关性。
对在乌度皮的T M A Pai医院出生的146名新生儿进行筛查，并记录其出生时的体重、身长、头围和腹围。分析脐带血样本中的总胆固醇、甘油三酯（TG）、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）。还根据胎龄（GA）和性别校正后的出生体重百分位数将婴儿进一步分为三组，即小于胎龄儿（SGA）、适于胎龄儿（AGA）和大于胎龄儿（LGA），以比较他们的血脂谱。纳入标准为出生时胎儿心率正常且阿氏评分>7。使用方差分析和皮尔逊相关系数对血脂谱与人体测量学之间关系的统计学意义进行分析。
ponderal指数（PI）较高的婴儿甘油三酯水平显著高于PI较低的婴儿（P = 0.011）。SGA婴儿的TG水平显著高于AGA组（P = 0.001）。腹围较大的新生儿的LDL水平显著低于腹围较小的新生儿（P = 0.019）。腹围较大的新生儿的平均HDL水平较高，但无统计学意义。母亲BMI对新生儿血脂谱无影响。
孕期母亲变化所产生的异常宫内环境可能对新生儿的脂质代谢产生深远影响，这可能解释了他们出生时血脂谱和人体测量学的差异。
