Goodman Phyllis J, Tangen Catherine M, Crowley John J, Carlin Susan M, Ryan Anne, Coltman Charles A, Ford Leslie G, Thompson Ian M
Southwest Oncology Group Statistical Center, M/S M3-C102, 1100 Fairview Avenue North, Box 19024, Seattle, WA 98109-1024, USA.
Control Clin Trials. 2004 Apr;25(2):203-22. doi: 10.1016/j.cct.2003.11.007.
The Prostate Cancer Prevention Trial is a randomized double blind chemoprevention trial of 18,882 men. It is designed to test the difference in the histologically proven prostate cancer prevalence between a group of participants given finasteride and another given placebo for 7 years. We present an overview of the study design, details of the administrative structure of the study and a description of the successful implementation of the accrual phase.
前列腺癌预防试验是一项针对18882名男性的随机双盲化学预防试验。该试验旨在测试服用非那雄胺的一组参与者与服用安慰剂7年的另一组参与者在组织学确诊的前列腺癌患病率上的差异。我们概述了研究设计、研究管理结构的细节以及入组阶段成功实施的描述。
