McCutchan Thomas F, Rathore Dharmendar, Li Jun
Growth and Development Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0425, USA.
Genetics. 2004 Jan;166(1):637-40. doi: 10.1534/genetics.166.1.637.
The fixation of neutral compensatory mutations in a population depends on the effective population size of the species, which can fluctuate dramatically within a few generations, the mutation rate, and the selection intensity associated with the individual mutations. We observe compensatory mutations and intermediate states in populations of the malaria parasite Plasmodium ovale. The appearance of compensatory mutations and intermediate states in P. ovale raises interesting questions about population structure that could have considerable impact on the control of the associated disease.
群体中中性补偿性突变的固定取决于物种的有效群体大小(其在几代之内可能会急剧波动)、突变率以及与各个突变相关的选择强度。我们在卵形疟原虫群体中观察到了补偿性突变和中间状态。卵形疟原虫中补偿性突变和中间状态的出现引发了有关群体结构的有趣问题,而这些问题可能会对相关疾病的控制产生重大影响。