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人类疟原虫卵形疟原虫的代偿进化。

Compensatory evolution in the human malaria parasite Plasmodium ovale.

作者信息

McCutchan Thomas F, Rathore Dharmendar, Li Jun

机构信息

Growth and Development Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0425, USA.

出版信息

Genetics. 2004 Jan;166(1):637-40. doi: 10.1534/genetics.166.1.637.

Abstract

The fixation of neutral compensatory mutations in a population depends on the effective population size of the species, which can fluctuate dramatically within a few generations, the mutation rate, and the selection intensity associated with the individual mutations. We observe compensatory mutations and intermediate states in populations of the malaria parasite Plasmodium ovale. The appearance of compensatory mutations and intermediate states in P. ovale raises interesting questions about population structure that could have considerable impact on the control of the associated disease.

摘要

群体中中性补偿性突变的固定取决于物种的有效群体大小(其在几代之内可能会急剧波动)、突变率以及与各个突变相关的选择强度。我们在卵形疟原虫群体中观察到了补偿性突变和中间状态。卵形疟原虫中补偿性突变和中间状态的出现引发了有关群体结构的有趣问题,而这些问题可能会对相关疾病的控制产生重大影响。

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RNA secondary structure and compensatory evolution.RNA二级结构与补偿性进化。
Genes Genet Syst. 1999 Dec;74(6):271-86. doi: 10.1266/ggs.74.271.
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Maintenance of pre-mRNA secondary structure by epistatic selection.通过上位性选择维持前体mRNA二级结构
Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9047-51. doi: 10.1073/pnas.92.20.9047.

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