果蝇中的RNA折叠对补偿性适应性相互作用表现出距离效应。
RNA folding in Drosophila shows a distance effect for compensatory fitness interactions.
作者信息
Stephan W, Kirby D A
机构信息
Department of Zoology, University of Maryland, College Park 20742.
出版信息
Genetics. 1993 Sep;135(1):97-103. doi: 10.1093/genetics/135.1.97.
Abstract
Phylogenetic-comparative analysis was used to construct a secondary structure of Adh precursor messenger RNA (pre-mRNA) in Drosophila. The analysis revealed that the rate of coevolution of base-pairing residues decreases with their physical distance. This result is in qualitative agreement with a model of compensatory fitness interactions which assumes that mutations are individually deleterious but become harmless (neutral) in appropriate combinations. This model predicts that coupled mutations can become fixed in a population under mutation pressure and random genetic drift, when the mutations are closely linked. However, the rate of joint fixation drops as distance between sites increases and recombination breaks up favorable combinations. RNA secondary structure was also used to interpret patterns of linkage disequilibrium at Adh.
摘要
系统发育比较分析被用于构建果蝇乙醇脱氢酶（Adh）前体信使核糖核酸（pre-mRNA）的二级结构。分析表明，碱基配对残基的协同进化速率随它们之间的物理距离而降低。这一结果在定性上与补偿适应性相互作用模型一致，该模型假定突变单独来看是有害的，但在适当组合时变得无害（中性）。该模型预测，当突变紧密连锁时，在突变压力和随机遗传漂变作用下，耦合突变能够在种群中固定下来。然而，随着位点间距离增加以及重组破坏有利组合，联合固定的速率会下降。RNA二级结构也被用于解释Adh位点的连锁不平衡模式。
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