Chan Andrew, Allen Roblee
Pulmonary Division, University of California, Davis, California, USA.
Curr Opin Pulm Med. 2004 Mar;10(2):133-41. doi: 10.1097/00063198-200403000-00008.
Bronchiolitis obliterans (BO) occurs in both post-lung transplant and nontransplant-related individuals, and is characterized by mainly irreversible airflow obstruction that is often ultimately progressive.
While post-lung transplant BO is a major cause of lung allograft dysfunction, and hence is better characterized than nontransplant-related BO, it is likely that many similarities in pathogenesis and treatment apply to both categories.
Optimal management for BO remains to be established, and the role of retransplantation in this disease requires further consensus. Minimization of risk factors for BO and earlier detection in the form of methacholine challenge testing and HRCT scans of the chest amongst other forms of detection, may help in the stabilization and possible resolution of early BO.
闭塞性细支气管炎（BO）发生于肺移植后及非移植相关个体，主要特征为不可逆性气流阻塞，且往往最终呈进行性发展。
虽然肺移植后BO是肺移植功能障碍的主要原因，因此比非移植相关BO的特征更明确，但发病机制和治疗方面可能存在许多相似之处。
BO的最佳治疗方案仍有待确定，再次移植在该病中的作用需要进一步达成共识。尽量减少BO的危险因素，并通过乙酰甲胆碱激发试验和胸部HRCT扫描等早期检测形式进行早期检测，可能有助于稳定早期BO并使其可能得到缓解。
