Takekawa T, Aoyagi T, Fukai T
Department of Applied Analysis and Complex Dynamical Systems, Graduate School of Informatics, Kyoto University, Yoshida-Honmachi, Sakyo-ku, Kyoto 606-8501, Japan.
Network. 2004 Feb;15(1):1-12.
We study how the location of synaptic input influences the stablex firing states in coupled model neurons bursting rhythmically at the gamma frequencies (20-70 Hz). The model neuron consists of two compartments and generates one, two, three or four spikes in each burst depending on the intensity of input current and the maximum conductance of M-type potassium current. If the somata are connected by reciprocal excitatory synapses, we find strong correlations between the changes in the bursting mode and those in the stable phase-locked states of the coupled neurons. The stability of the in-phase phase-locked state (synchronously firing state) tends to change when the individual neurons change their bursting patterns. If, however, the synaptic connections are terminated on the dendritic compartments, no such correlated changes occur. In this case, the coupled bursting neurons do not show the in-phase phase-locked state in any bursting mode. These results indicate that synchronization behaviour of bursting neurons significantly depends on the synaptic location, unlike a coupled system of regular spiking neurons.
我们研究了在以伽马频率（20 - 70赫兹）有节奏地爆发的耦合模型神经元中，突触输入的位置如何影响稳定的放电状态。该模型神经元由两个隔室组成，根据输入电流的强度和M型钾电流的最大电导，在每个爆发中产生一个、两个、三个或四个尖峰。如果胞体通过相互兴奋性突触连接，我们发现爆发模式的变化与耦合神经元稳定锁相状态的变化之间存在很强的相关性。当单个神经元改变其爆发模式时，同相锁相状态（同步放电状态）的稳定性往往会发生变化。然而，如果突触连接终止于树突隔室，则不会发生这种相关变化。在这种情况下，耦合的爆发神经元在任何爆发模式下都不会表现出同相锁相状态。这些结果表明，与规则发放神经元的耦合系统不同，爆发神经元的同步行为显著取决于突触位置。
