Atanes A, de Toro J, Gómez N, Aspe B, Graña J, Burson J M, Galdo F
Unidad de Reumatología, Hospital Juan Canalejo, La Coruña.
Rev Clin Esp. 1992 Jun;191(2):65-70.
We studied 94 patients diagnosed of sarcoidosis in order to establish the incidence of erythema nodosum (EN), in the course of sarcoidosis, in our setting and to check if it induces different clinical and analytical characteristics in patients. 37 patients (39%) showed EN with a mean age of 41 +/- 1.62 years and with a marked female predominance (81%). Its presence was associated with a higher frequency of general symptoms (p less than 0.01), articular manifestations (p less than 0.001), specially in knees and ankles (p less than 0.01), subacute evolution (p less than 0.001), raise in GSR and of alpha-one-globulin (p less than 0.01) and hypoalbuminemia (p less than 0.05). On the other hand, those patients without EN showed higher frequency of dermal lesions different from EN (p less than 0.001) and the articular manifestations were localized preferentially in knees and proximal interphalangeal articulations of hands (p less than 0.05). We underline the high incidence of EN in sarcoidosis in our setting, which originates a more benign clinical type with a more favorable prognostic, embedded in the course of sarcoidosis, to which EN would transfer its clinical, analytical and immunopathogenic characteristics.
我们研究了94例被诊断为结节病的患者，以确定在我们的研究环境中结节病病程中结节性红斑（EN）的发病率，并检查其是否会在患者中引发不同的临床和分析特征。37例患者（39%）出现EN，平均年龄为41±1.62岁，女性明显占优势（81%）。EN的出现与更高频率的全身症状（p<0.01）、关节表现（p<0.001）相关，特别是在膝盖和脚踝（p<0.01）、亚急性病程（p<0.001）、GSR和α-1球蛋白升高（p<0.01）以及低白蛋白血症（p<0.05）有关。另一方面，那些没有EN的患者出现与EN不同的皮肤病变的频率更高（p<0.001），并且关节表现优先出现在膝盖和手部近端指间关节（p<0.05）。我们强调在我们的研究环境中结节病中EN的高发病率，它在结节病病程中产生一种更良性的临床类型，预后更有利，EN会将其临床、分析和免疫致病特征传递给该类型。
