Olive K E, Kataria Y P
Arch Intern Med. 1985 Oct;145(10):1811-4.
The charts of 329 patients with sarcoidosis were reviewed to determine if there were significant associations between the presence of sarcoidosis skin lesions and other abnormalities. Sixty-four patients had either biopsy specimen-documented cutaneous granulomata or erythema nodosum (EN). Respiratory symptoms occurred in 41% of patients with skin lesions compared with 63% of patients with sarcoidosis without skin lesions. Among patients with skin lesions other than EN, splenomegaly occurred in 38%, hepatomegaly in 32%, and lymphadenopathy in 31% compared with 10%, 11%, and 56%, respectively, for patients with sarcoidosis without skin lesions. Thirty-two percent of patients with EN had progressive disease compared with 72% of patients with skin lesions other than EN; however, improved prognosis with EN was limited to white patients.
回顾了329例结节病患者的病历，以确定结节病皮肤病变的存在与其他异常之间是否存在显著关联。64例患者有活检标本证实的皮肤肉芽肿或结节性红斑（EN）。有皮肤病变的患者中41%出现呼吸道症状，而无皮肤病变的结节病患者中这一比例为63%。在除EN外有皮肤病变的患者中，脾肿大发生率为38%，肝肿大为32%，淋巴结病为31%，而无皮肤病变的结节病患者中这一比例分别为10%、11%和56%。32%的EN患者病情进展，而除EN外有皮肤病变的患者中这一比例为72%；然而，EN患者预后改善仅限于白人患者。
