亚硝化应激与钾通道介导的神经元凋亡：锌是其中的联系吗？
Nitrosative stress and potassium channel-mediated neuronal apoptosis: is zinc the link?
作者信息
Pal Sumon, He Kai, Aizenman Elias
机构信息
Department of Neurobiology, University of Pittsburgh School of Medicine, E1456 BST, Pittsburgh, PA 15261, USA.
出版信息
Pflugers Arch. 2004 Jun;448(3):296-303. doi: 10.1007/s00424-004-1256-7. Epub 2004 Mar 13.
Abstract
Nitrosative stress has been implicated in a large number of neurological disorders. The molecular mechanisms underlying the neuronal injury associated with this stimulus, however, are not clearly understood. Emerging evidence suggests that the liberation of intracellular zinc as well as over-activation of potassium channels may be two important components of nitrosative stress-induced neuronal death.
摘要
亚硝化应激与大量神经系统疾病有关。然而，与这种刺激相关的神经元损伤的分子机制尚不清楚。新出现的证据表明，细胞内锌的释放以及钾通道的过度激活可能是亚硝化应激诱导神经元死亡的两个重要组成部分。
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