Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, Korea.
Int J Mol Sci. 2020 Nov 25;21(23):8941. doi: 10.3390/ijms21238941.
Zinc is a trace metal ion in the central nervous system that plays important biological roles, such as in catalysis, structure, and regulation. It contributes to antioxidant function and the proper functioning of the immune system. In view of these characteristics of zinc, it plays an important role in neurophysiology, which leads to cell growth and cell proliferation. However, after brain disease, excessively released and accumulated zinc ions cause neurotoxic damage to postsynaptic neurons. On the other hand, zinc deficiency induces degeneration and cognitive decline disorders, such as increased neuronal death and decreased learning and memory. Given the importance of balance in this context, zinc is a biological component that plays an important physiological role in the central nervous system, but a pathophysiological role in major neurological disorders. In this review, we focus on the multiple roles of zinc in the brain.
锌是中枢神经系统中的一种痕量金属离子，具有重要的生物学作用，如催化、结构和调节。它有助于抗氧化功能和免疫系统的正常运作。鉴于锌的这些特性，它在神经生理学中起着重要作用，促进细胞生长和增殖。然而，在脑部疾病发生后，过量释放和积累的锌离子会对突触后神经元造成神经毒性损伤。另一方面，锌缺乏会导致神经元死亡增加和学习记忆能力下降等退行性和认知障碍疾病。鉴于这种情况下平衡的重要性，锌是中枢神经系统中具有重要生理作用的生物成分，但在重大神经障碍中具有病理生理作用。在这篇综述中，我们重点介绍锌在大脑中的多种作用。
