Department of Neuroscience and Imaging, Molecular Neurology Unit, CeSI-Center for Excellence on Aging, University "G. d'Annunzio," Chieti 66013, Italy.
J Neurosci. 2011 Nov 9;31(45):16076-85. doi: 10.1523/JNEUROSCI.3454-11.2011.
Our understanding of the roles played by zinc in the physiological and pathological functioning of the brain is rapidly expanding. The increased availability of genetically modified animal models, selective zinc-sensitive fluorescent probes, and novel chelators is producing a remarkable body of exciting new data that clearly establishes this metal ion as a key modulator of intracellular and intercellular neuronal signaling. In this Mini-Symposium, we will review and discuss the most recent findings that link zinc to synaptic function as well as the injurious effects of zinc dyshomeostasis within the context of neuronal death associated with major human neurological disorders, including stroke, epilepsy, and Alzheimer's disease.
我们对锌在大脑生理和病理功能中所扮演角色的理解正在迅速扩展。越来越多的遗传修饰动物模型、选择性锌敏感荧光探针和新型螯合剂的出现,产生了大量令人兴奋的新数据,这些数据清楚地表明,这种金属离子是细胞内和细胞间神经元信号传递的关键调节剂。在本次小型座谈会上,我们将回顾和讨论最新发现,这些发现将锌与突触功能联系起来,并探讨在与人类主要神经疾病(包括中风、癫痫和阿尔茨海默病)相关的神经元死亡的背景下,锌动态平衡紊乱的有害影响。