Boman F, Bossard C, Fabre M, Diab N, Bonnevalle M, Boccon-Gibod L
Department of Pathology, Faculté de Médecine et Hôpital Calmette, CHRU de Lille, France.
Eur J Pediatr Surg. 2004 Feb;14(1):63-6. doi: 10.1055/s-2004-815784.
A mesenchymal hamartoma (MH) of the liver in a seven-month-old girl was associated with slightly elevated alpha fetoprotein (AFP) concentrations (320 microg/L, normal < 25 after six months of age). Hepatocytes were abundant at the periphery of the tumour at histopathological examination. These were slightly atypical and expressed AFP immunohistochemically. In two other girls, aged 14 months and two months respectively, with MH and increased serum AFP concentrations (320 microg/L and 7500 microg/L, respectively), hepatoblastomas were misdiagnosed preoperatively. MH of the liver with increased serum AFP concentrations may thus mimic hepatoblastoma radiologically if cysts are lacking, and foetal hepatoblastoma pathologically if a biopsy samples only the peripheral hepatocellular component of the MH.
一名7个月大女童的肝脏间叶性错构瘤（MH）与甲胎蛋白（AFP）浓度轻度升高有关（320μg/L，6个月龄后正常<25μg/L）。组织病理学检查显示肿瘤周边肝细胞丰富。这些肝细胞有轻度异型性，免疫组化显示表达AFP。另外两名女童，分别为14个月和2个月大，患有MH且血清AFP浓度升高（分别为320μg/L和7500μg/L），术前被误诊为肝母细胞瘤。因此，如果缺乏囊肿，血清AFP浓度升高的肝脏MH在放射学上可能类似肝母细胞瘤；如果活检仅取到MH的外周肝细胞成分，在病理上可能类似胎儿型肝母细胞瘤。
