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海洋来源的生物活性肽:药理特性与分离方法

Bioactive peptides from marine sources: pharmacological properties and isolation procedures.

作者信息

Aneiros Abel, Garateix Anoland

机构信息

Centre of Marine Bioactive Substances (CEBIMAR), Ministry of Science Technology and Environment, PO Box 10600, Loma y 37, Alturas del Vedado, Ciudad, Habana, Cuba.

出版信息

J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Apr 15;803(1):41-53. doi: 10.1016/j.jchromb.2003.11.005.

Abstract

Marine organisms represent a valuable source of new compounds. The biodiversity of the marine environment and the associated chemical diversity constitute a practically unlimited resource of new active substances in the field of the development of bioactive products. In this paper, the molecular diversity of different marine peptides is described as well as information about their biological properties and mechanisms of action is provided. Moreover, a short review about isolation procedures of selected bioactive marine peptides is offered. Novel peptides from sponges, ascidians, mollusks, sea anemones and seaweeds are presented in association with their pharmacological properties and obtainment methods.

摘要

海洋生物是新化合物的宝贵来源。海洋环境的生物多样性以及相关的化学多样性构成了生物活性产品开发领域中几乎无限的新活性物质资源。本文描述了不同海洋肽的分子多样性,并提供了有关其生物学特性和作用机制的信息。此外,还对选定的生物活性海洋肽的分离程序进行了简要综述。介绍了来自海绵、海鞘、软体动物、海葵和海藻的新型肽及其药理特性和获取方法。

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