Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China.
Department of Pharmacology, Capital Medical University, Beijing 100069, China.
Mar Drugs. 2011;9(10):1840-1859. doi: 10.3390/md9101840. Epub 2011 Oct 10.
The biodiversity of the marine environment and the associated chemical diversity constitute a practically unlimited resource of new antitumor agents in the field of the development of marine bioactive substances. In this review, the progress on studies of antitumor peptides from marine sources is provided. The biological properties and mechanisms of action of different marine peptides are described; information about their molecular diversity is also presented. Novel peptides that induce apoptosis signal pathway, affect the tubulin-microtubule equilibrium and inhibit angiogenesis are presented in association with their pharmacological properties. It is intended to provide useful information for further research in the fields of marine antitumor peptides.
海洋环境的生物多样性和相关的化学多样性构成了海洋生物活性物质开发领域中新型抗肿瘤药物的几乎无限的资源。在这篇综述中，提供了海洋来源的抗肿瘤肽研究进展。描述了不同海洋肽的生物学特性和作用机制，并介绍了它们的分子多样性信息。还介绍了一些诱导细胞凋亡信号通路、影响微管-微管平衡和抑制血管生成的新型肽及其药理学特性。旨在为海洋抗肿瘤肽领域的进一步研究提供有用的信息。
