男性患帕金森病的风险比女性更高吗？
Are men at greater risk for Parkinson's disease than women?
作者信息
Wooten G F, Currie L J, Bovbjerg V E, Lee J K, Patrie J
机构信息
Department of Neurology, Box 800394, University Health System, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
出版信息
J Neurol Neurosurg Psychiatry. 2004 Apr;75(4):637-9. doi: 10.1136/jnnp.2003.020982.
Parkinson's disease seems to occur more commonly in men than women based primarily on studies of death rates and prevalence. In recent years, several population based incidence studies of Parkinson's disease that included sex data have been conducted in a variety of populations around the world. To investigate whether these incidence studies suggest an increased risk of Parkinson's disease in men, a meta-analysis was performed of the differences in incidence of Parkinson's disease between men and women reported in seven studies that met the inclusion criteria. A significantly higher incidence rate of Parkinson's disease was found among men with the relative risk being 1.5 times greater in men than women. Possible reasons for this increased risk of Parkinson's disease in men are toxicant exposure, head trauma, neuroprotection by oestrogen, mitochondrial dysfunction, or X linkage of genetic risk factors.
基于死亡率和患病率的研究，帕金森病在男性中似乎比女性更常见。近年来，世界各地的各种人群中开展了几项包含性别数据的帕金森病基于人群的发病率研究。为了调查这些发病率研究是否表明男性患帕金森病的风险增加，对七项符合纳入标准的研究中报告的男性和女性帕金森病发病率差异进行了荟萃分析。结果发现男性帕金森病的发病率显著更高，男性的相对风险比女性高1.5倍。男性患帕金森病风险增加的可能原因是接触毒物、头部外伤、雌激素的神经保护作用、线粒体功能障碍或遗传风险因素的X连锁。
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