Department of Neurology, University of Turku and Turku University Hospital, Finland.
Parkinsonism Relat Disord. 2012 Feb;18(2):155-60. doi: 10.1016/j.parkreldis.2011.09.007. Epub 2011 Oct 7.
Impulse control disorders occur frequently in patients with Parkinson's disease. However, the frequencies have been investigated mainly in patients from secondary or tertiary care centers, and thus, the prevalence rates in general community are not known.
Our objective was to study the prevalence rates of impulse control disorders and related factors in a large, non-selected sample of Parkinson's disease patients.
We conducted a cross-sectional survey among Parkinson's disease patients from Finnish Parkinson Association [n = 575; 365 men, 240 women, median age 64 (range 43-90) years]. Problem and pathological gambling were estimated with the South Oaks Gambling Screen, risk for impulse control disorders with the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease, and depression with the Beck Depression Inventory.
The frequency of pathological gambling was 7.0%. The overall frequency of a positive screen for an impulse control disorder was 34.8%, and 12.5% of the patients screened positive for multiple disorders. Depressive symptoms were statistically the most important factor in explaining variance in impulse control disorder risk, even more than sex, age, age of disease onset, alcohol use, or medication.
The high proportion of patients screened positive for impulse control disorders in a non-selected sample emphasize the importance of routine screening of these disorders in Parkinson's disease. Pathological gambling prevalence in Parkinson's disease is seven times higher than in the general population in Finland. The results underline the importance of depression in impulse control disorders associated with Parkinson's disease.
冲动控制障碍在帕金森病患者中经常发生。然而，这些频率主要是在二级或三级护理中心的患者中进行调查的，因此，一般社区中的患病率尚不清楚。
我们的目的是在一个大型的、未经选择的帕金森病患者样本中研究冲动控制障碍的患病率及其相关因素。
我们对芬兰帕金森协会的帕金森病患者（n=575；365 名男性，240 名女性，中位年龄 64（范围 43-90）岁）进行了横断面调查。使用 South Oaks 赌博筛查量表评估问题性和病理性赌博，使用经过验证的帕金森病冲动-强迫障碍问卷评估冲动控制障碍风险，使用贝克抑郁量表评估抑郁。
病理性赌博的频率为 7.0%。冲动控制障碍阳性筛查的总频率为 34.8%，12.5%的患者筛查出多种障碍。抑郁症状是解释冲动控制障碍风险变异的最重要因素，甚至比性别、年龄、发病年龄、酒精使用或药物更重要。
在非选择性样本中，筛查出患有冲动控制障碍的患者比例较高，这强调了在帕金森病中常规筛查这些障碍的重要性。帕金森病患者中病理性赌博的患病率是芬兰一般人群的七倍。这些结果强调了抑郁在与帕金森病相关的冲动控制障碍中的重要性。
