Guo Xiaofang, Liu Xinghua, Lin Jian, Huang Zitian, Lin Sixing, Zhang Mengfan, Xu Zihan, Lin Xingdong
The Third Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
Department of Neurology, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Front Public Health. 2025 Apr 9;13:1561216. doi: 10.3389/fpubh.2025.1561216. eCollection 2025.
The burden of neurological diseases in women is underestimated. This study aimed to estimate the pattern and trend of four major nervous system diseases in women.
Utilizing data from the GBD Study 2021 on the incidence and disability-adjusted life-years (DALYs) of Alzheimer's disease (AD) and other dementias, Parkinson's disease, multiple sclerosis, and idiopathic epilepsy in women from 1990 to 2021. We estimated trends by age and socio-demographic index (SDI), globally, regionally, and nationally, using Estimated annual percentage changes (EAPC), Spearman correlation analysis and projected future trends with the Bayesian age-period-cohort (BAPC) model.
In 2021, an estimated 6191564.2, 572999.9, 1536118.7, and 39191.7 new cases of female AD and other dementias, Parkinson's disease, multiple sclerosis, and idiopathic epilepsy were reported globally, with a significant increase in age-standardized incidence rate (ASIR) from 1990 to 2021. Contrary, the age-standardized DALY rate (ASDR) decreased in idiopathic epilepsy and multiple sclerosis. AD and other dementias and Parkinson's disease were prevalent among women worldwide, followed by idiopathic epilepsy and multiple sclerosis, with regional and country disparities. There are also difference of patterns among age and SDI. The BAPC model projects that by 2050, the ASIR of the four major neurological disorders will continue to increase.
The burden of major neurological diseases in women is a serious global health challenge. Given the regional disparities and varying age patterns in incidence and DALYs, there is an urgent need for tailored prevention and healthcare approaches to mitigate the burden worldwide.
女性神经系统疾病的负担被低估。本研究旨在评估女性四种主要神经系统疾病的模式和趋势。
利用全球疾病负担研究（GBD Study 2021）中1990年至2021年女性阿尔茨海默病（AD）和其他痴呆症、帕金森病、多发性硬化症和特发性癫痫的发病率及伤残调整生命年（DALYs）数据。我们通过年龄和社会人口指数（SDI），在全球、区域和国家层面，使用估计年百分比变化（EAPC）、Spearman相关性分析，并采用贝叶斯年龄-时期-队列（BAPC）模型预测未来趋势，来评估趋势。
2021年，全球估计有6191564.2例、572999.9例、1536118.7例和39191.7例女性新发AD和其他痴呆症、帕金森病、多发性硬化症和特发性癫痫病例，1990年至2021年年龄标准化发病率（ASIR）显著上升。相反，特发性癫痫和多发性硬化症的年龄标准化伤残调整生命年率（ASDR）下降。AD和其他痴呆症以及帕金森病在全球女性中普遍存在，其次是特发性癫痫和多发性硬化症，存在区域和国家差异。年龄和SDI之间也存在模式差异。BAPC模型预测，到2050年，四种主要神经系统疾病的ASIR将继续上升。
女性主要神经系统疾病的负担是一项严峻的全球健康挑战。鉴于发病率和DALYs存在区域差异以及不同的年龄模式，迫切需要采取针对性的预防和医疗保健方法来减轻全球负担。
