Park K, Lim D J
Department of Otolaryngology, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Med J. 1992 Mar;33(1):64-71. doi: 10.3349/ymj.1992.33.1.64.
In order to describe the developmental anatomy of the murine eustachian tube and its related structures, seventy six mice of ages ranging from gestational day 11 to postnatal day 21 were investigated through the light and electron microscopic observations. Development of the ciliated cells was seen concurrently in both the eustachian tube and middle ear on the 16 th gestation day, one day earlier than the epithelial secretory cells appeared in both the eustachian tube and middle ear. The number of ciliated cells and secretory cells increased rapidly after birth. Tubal glands were well identified with evidence of secretory activity around the time of birth. Thus, the findings of this study indicate that the mucociliary defense system starts to develop during the fetal stage and is well established immediately after birth.
为了描述小鼠咽鼓管及其相关结构的发育解剖学，通过光镜和电镜观察对76只年龄从妊娠第11天到出生后第21天的小鼠进行了研究。在妊娠第16天，咽鼓管和中耳同时可见纤毛细胞的发育，比咽鼓管和中耳上皮分泌细胞出现早一天。出生后纤毛细胞和分泌细胞的数量迅速增加。出生前后可清楚识别出有分泌活动迹象的咽鼓管腺体。因此，本研究结果表明，黏液纤毛防御系统在胎儿期开始发育，并在出生后立即完善。
