Maeda S, Mogi G, Oh M
Ann Otol Rhinol Laryngol. 1976 Sep-Oct;85(5 SUPPL 31 PT 3):1-19. doi: 10.1177/00034894760855S201.
Forty-two fetal and 90 developing young rats were studied electron microscopically to obtain a normal cellular distribution pattern of middle ear mucosa. The results showed that while ciliated columnar or cuboidal cells interspersed with secretory cells were predominantly distributed around the tympanic orifice and transitional zone, cuboidal or squamous nonciliated cells without secretory granules were numerous in the remaining part of the bulla. Development of ciliated cells started at the 17th or 18 th fetal day,paralleling that of secretory cells. The number of ciliated and secretory cells increased rapidly after birth. Glands were not found in the osseous tube, tympanic orifice, or other portions of the middle ear cavity in fetal, newborn, or suckling rats, while they are abundant in the cartilaginous portion of the tube. The findings of this study indicate that both secretory and ciliated cells are normal components of middle ear mucosa although these cells are restricted to the tympanic orifice and transitional zone, and that the mucociliary defense system starts to develop during the fetal stage.
对42只胎鼠和90只发育中的幼鼠进行了电子显微镜研究，以获得中耳黏膜的正常细胞分布模式。结果显示，虽然散布有分泌细胞的纤毛柱状或立方体细胞主要分布在鼓膜口和过渡区周围，但在鼓泡的其余部分，没有分泌颗粒的立方或鳞状无纤毛细胞数量众多。纤毛细胞的发育始于胎儿第17或18天，与分泌细胞的发育平行。出生后，纤毛细胞和分泌细胞的数量迅速增加。在胎鼠、新生鼠或乳鼠的骨管、鼓膜口或中耳腔的其他部位未发现腺体，而在管的软骨部分腺体丰富。本研究结果表明，尽管这些细胞仅限于鼓膜口和过渡区，但分泌细胞和纤毛细胞都是中耳黏膜的正常组成部分，并且黏液纤毛防御系统在胎儿期开始发育。
