Alhadi H A, Fox K A A
Cardiovascular Research Unit, Centre for Cardiovascular Science, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK.
QJM. 2004 Apr;97(4):187-98. doi: 10.1093/qjmed/hch037.
Heart fatty-acid-binding protein (FABP) is a small cytosolic protein that is abundant in the heart and has low concentrations in the blood and in tissues outside the heart. It appears in the blood as early as 1.5 h after onset of symptoms of infarction, peaks around 6 h and returns to baseline values in 24 h. These features of H-FABP make it an excellent potential candidate for the detection of acute myocardial infarction (AMI). We review the strengths and weaknesses of H-FABP as a clinically applicable marker of myocyte necrosis in the context of acute coronary syndromes.
心脏脂肪酸结合蛋白（FABP）是一种小的胞质蛋白，在心脏中含量丰富，而在血液和心脏以外的组织中浓度较低。它在梗死症状出现后1.5小时最早出现在血液中，约6小时达到峰值，并在24小时内恢复到基线值。H-FABP的这些特性使其成为检测急性心肌梗死（AMI）的极佳潜在候选物。我们在急性冠状动脉综合征的背景下，综述了H-FABP作为心肌细胞坏死临床适用标志物的优缺点。
