Kereiakes Dean J, Choo Joseph K, Young John J, Broderick Thomas M
Lindner Center for Research & Education, Ohio Heart Health Center, Cincinnati, Ohio, USA.
Rev Cardiovasc Med. 2004 Winter;5(1):9-15.
The clinical consequences of stent thrombosis are frequently catastrophic. This article reviews the factors previously implicated in the occurrence of stent thrombosis and analyzes recent reports of thrombosis involving a new sirolimus-eluting stent (Cypher). Factors associated with stent thrombosis include intrinsic stent thrombogenicity and patient-, target lesion-, and procedure-related issues. Stent design may influence the degree of platelet activation after coronary stent deployment. In drug-eluting stents, the mechanical properties of the bare metal stent platform might be altered by the polymer coating, and the propensity for thrombosis might be influenced by both the polymer coating and the medication with which it is impregnated. Cumulative data for the Cypher stent do not suggest a propensity for thrombosis, but several caveats should be observed to enhance the safety of the device.
支架血栓形成的临床后果常常是灾难性的。本文回顾了先前与支架血栓形成相关的因素，并分析了近期有关一种新型西罗莫司洗脱支架（Cypher）血栓形成的报告。与支架血栓形成相关的因素包括支架本身的血栓形成倾向以及患者、靶病变和手术相关问题。支架设计可能会影响冠状动脉支架置入后血小板的激活程度。在药物洗脱支架中，裸金属支架平台的机械性能可能会因聚合物涂层而改变，血栓形成倾向可能会受到聚合物涂层及其所含药物的影响。Cypher支架的累积数据并未表明其有血栓形成倾向，但应注意一些注意事项以提高该装置的安全性。
