Yamasaki A
Department of Ophthalmology, Faculty of Medicine, Tottori University, Yonago, Japan.
Nippon Ganka Gakkai Zasshi. 1992 Jul;96(7):845-51.
Using adult albino rabbits, the clinical course of lens opacity and morphological changes of lens epithelial cells were observed from 2 weeks to 3 months after intravitreal silicone oil injection. Simple vitrectomy was performed in both rabbit eyes. One eye with silicone oil injection served as an experimental eye, while another control eye did not receive any injection. Seven examined eyes showed early posterior subcapsular lens opacity from one month after silicone oil injection by slit-lamp microscopy. Small intracellular vacuoles near to the interdigitation of the lens epithelial cells were observed in the 7 eyes from 2 weeks after the procedure by transmission electron microscopy. These changes were not observed in 7 control eyes. As a result, it is surmised that cataract formation after intravitreal silicone oil injection may be associated with morphological changes of the lens epithelial cells.
使用成年白化兔，在玻璃体内注射硅油后2周~3个月观察晶状体混浊的临床过程及晶状体上皮细胞的形态学变化。对两只兔眼均进行单纯玻璃体切除术。一只眼注射硅油作为实验眼，另一只对照眼不进行任何注射。通过裂隙灯显微镜检查，7只受检眼在注射硅油1个月后出现早期后囊下晶状体混浊。透射电子显微镜检查显示，术后2周，这7只眼中晶状体上皮细胞指状交叉附近出现小的细胞内空泡。7只对照眼中未观察到这些变化。因此，推测玻璃体内注射硅油后白内障形成可能与晶状体上皮细胞的形态学变化有关。
