Yamasaki A, Nagata M, Takagi S, Tamai A
Department of Ophthalmology, Faculty of Medicine, Tottori University, Yonago, Japan.
Jpn J Ophthalmol. 1994;38(2):116-22.
The clinical course of lens opacity and the morphological changes in lens epithelial cells after intravitreal silicone oil injection were observed for 3 months in 21 normal adult albino rabbits. After the simple vitrectomy in both eyes of each rabbit, silicone oil was injected into the vitreous in one eye and the other eye was kept as the control. By photoslit-lamp microscopy, 8 of the 14 examined eyes showed early posterior subcapsular lens opacity one month after silicone oil injection. By transmission electron microscopy, intracellular vesicles near the interdigitation of the lens epithelial cells were observed in all of the 7 eyes examined histologically 2 weeks after the procedure. These changes were not observed in the 7 fellow control eyes. As a result, it is surmised that cataract formation after intravitreal silicone oil injection may be associated with morphological changes in the lens epithelial cells.
对21只正常成年白化兔进行了3个月的观察，以了解玻璃体内注射硅油后晶状体混浊的临床过程以及晶状体上皮细胞的形态变化。在每只兔子的双眼进行单纯玻璃体切除术后，向一只眼睛的玻璃体腔内注入硅油，另一只眼睛作为对照。通过裂隙灯显微镜检查，在注射硅油1个月后，14只被检查的眼睛中有8只出现早期后囊下晶状体混浊。通过透射电子显微镜检查，在手术后2周进行组织学检查的所有7只眼睛中，均观察到晶状体上皮细胞指状交叉处附近的细胞内小泡。在7只对照眼中未观察到这些变化。因此，推测玻璃体内注射硅油后白内障的形成可能与晶状体上皮细胞的形态变化有关。
