Furukawa H, Tagawa H, Fujii H
Department of Computer Science and Electronics, Kyushu Institute of Technology, Japan.
Nippon Ganka Gakkai Zasshi. 1992 Jul;96(7):872-7.
We developed laser speckle flowgraphy which displays the relative velocity of blood microcirculation as a color map in two dimensions. We applied this method to the iris in 10 eyes of 5 normal white rabbits under general anesthesia. The coefficient of variation was small and averaged 5.6. There was no significant difference in the values measured on 3 consecutive days. The blood velocity in the iris increased significantly during experimental ocular hypotony and decreased during ocular hypertension and 2 hours after instillation of timolol (p less than 0.05). These findings indicate that the present method is of value in assessing the relative velocity of iris microcirculation in vivo and that topical instillation of timolol induces decrease of blood flow in the iris and, possibly, in the ciliary body.
我们开发了激光散斑血流图，它可以二维彩色图谱的形式显示血液微循环的相对速度。我们在全身麻醉下，将此方法应用于5只正常白兔的10只眼睛的虹膜。变异系数较小，平均为5.6。连续3天测量的值无显著差异。实验性眼压降低时虹膜血流速度显著增加，而眼压升高时及滴注噻吗洛尔2小时后血流速度降低（p<0.05）。这些结果表明，本方法在评估体内虹膜微循环相对速度方面具有价值，并且局部滴注噻吗洛尔可导致虹膜及可能的睫状体血流减少。
