Tomidokoro A, Tamaki Y, Tomita K, Nagahara M, Araie M, Fujii H
Eye Clinic, Omiya Red Cross Hospital, Saitama-ken, Japan.
Nippon Ganka Gakkai Zasshi. 1995 Feb;99(2):143-8.
We have developed an apparatus using the laser speckle phenomenon for noninvasive two-dimensional measurement of the peripheral circulation of the iris. The normalized blur of the speckle pattern (NB-value) was adopted as an index of the blood velocity in the tissue. It was found that the average NB-value of the pigmented rabbit iris was gradually increasing from pupil margin to periphery. The coefficient of variation of the NB-value in the middle area of the iridial width was the smallest. The coefficient of reproducibility of the NB-value measured in the same area twice at 5-minute intervals was 8.8%, and that at 24-hour intervals was 14.1%. The NB-value of the iris showed a good correlation (r = 0.57, p < 0.0072 n = 20) with the iridial blood flow rate measured at the same time by the microsphere technique when intraocular pressure was adjusted to 20 mmHg or 40 mmHg. This result suggests that the NB-value can be useful for quantitative assessment not only of the blood velocity but also of the blood flow rate in the iridial tissues.
我们开发了一种利用激光散斑现象对虹膜外周循环进行无创二维测量的装置。散斑图案的归一化模糊度（NB值）被用作组织中血流速度的指标。结果发现，有色家兔虹膜的平均NB值从瞳孔边缘到周边逐渐增加。虹膜宽度中间区域的NB值变异系数最小。每隔5分钟在同一区域测量一次NB值的重复性系数为8.8%，每隔24小时测量一次的重复性系数为14.1%。当眼压调整到20 mmHg或40 mmHg时，虹膜的NB值与同时通过微球技术测量的虹膜血流速率具有良好的相关性（r = 0.57，p < 0.0072，n = 20）。该结果表明，NB值不仅可用于定量评估虹膜组织中的血流速度，还可用于评估血流速率。
