氯胺酮、替来他明-唑拉西泮合剂、赛拉嗪和地托咪定。一项针对小马的麻醉药物联合使用对比研究。
Ketamine, Telazol, xylazine and detomidine. A comparative anesthetic drug combinations study in ponies.
作者信息
Lin H C, Branson K R, Thurmon J C, Benson G J, Tranquilli W J, Olson W A, Vähä-Vahe A T
机构信息
Department of Large Animal Surgery and Medicine, College of Veterinary Medicine, Auburn University, Alabama.
出版信息
Acta Vet Scand. 1992;33(2):109-15. doi: 10.1186/BF03547317.
This study was designed to assess the effects of 5 anesthetic drug combinations in ponies: (1) ketamine 2.75 mg/kg, xylazine 1.0 mg/kg (KX), (2) Telazol 1.65 mg/kg, xylazine 1.0 mg/kg (TX), (3) Telazol 2 mg/kg, detomidine 20 micrograms/kg (TD-20), (4) Telazol 2 mg/kg, detomidine 40 micrograms/kg (TD-40), (5) Telazol 3 mg/kg, detomidine 60 micrograms/kg (TD-60). All drugs were given iv with xylazine or detomidine preceding ketamine or Telazol by 5 min. Heart rate was decreased significantly from 5 min to arousal after TD-20 but only at 60 and 90 min after TD-40 and TD-60 respectively. Respiratory rate was decreased significantly for all ponies. Induction time did not differ between treatments. Duration of analgesia was 10 min for KX, 22.2 min for TX, 27.5 min for TD-20, 32.5 min for TD-40, and 70 min for TD-60. Arousal time was significantly longer with detomidine and Telazol. Smoothness of recovery was judged best in ponies receiving KX and TD-40. All ponies stood unassisted 30 min after signs of arousal.
本研究旨在评估5种麻醉药物组合对矮种马的影响：（1）氯胺酮2.75 mg/kg、赛拉嗪1.0 mg/kg（KX），（2）替来他明1.65 mg/kg、赛拉嗪1.0 mg/kg（TX），（3）替来他明2 mg/kg、地托咪定20微克/千克（TD - 20），（4）替来他明2 mg/kg、地托咪定40微克/千克（TD - 40），（5）替来他明3 mg/kg、地托咪定60微克/千克（TD - 60）。所有药物均静脉注射，赛拉嗪或地托咪定在氯胺酮或替来他明之前5分钟给予。TD - 20组给药后5分钟至苏醒期间心率显著下降，但TD - 40组和TD - 60组分别仅在给药后60分钟和90分钟时心率显著下降。所有矮种马的呼吸频率均显著下降。各治疗组的诱导时间无差异。KX组的镇痛持续时间为10分钟，TX组为22.2分钟，TD - 20组为27.5分钟，TD - 40组为32.5分钟，TD - 60组为70分钟。使用地托咪定和替来他明时苏醒时间显著延长。接受KX组和TD - 40组的矮种马恢复平稳程度最佳。所有矮种马在出现苏醒迹象后30分钟可自主站立。
Zotero 插件