J Am Vet Med Assoc. 2021 Apr 15;258(8):883-891. doi: 10.2460/javma.258.8.883.
To evaluate and compare the anesthetic, analgesic, and cardiorespiratory effects of tiletamine-zolazepam-detomidine-butorphanol (TZDB), tiletamine-zolazepam-xylazine-butorphanol (TZXB), and ketamine-detomidine-butorphanol (KDB) in pigs and to assess anesthetic recovery duration and quality following administration of tolazoline as a reversal agent.
11 healthy 2.5-month-old castrated male Landrace mixed-breed pigs.
In a randomized, blinded crossover study design, pigs received the following anesthetic combinations, IM: TZDB (tiletamine-zolazepam [3 mg/kg {1.36 mg/lb}], detomidine [0.18 mg/kg {0.08 mg/lb}], and butorphanol [0.12 mg/kg {0.05 mg/lb}]); TZXB (tiletamine-zolazepam [4 mg/kg {1.8 mg/lb}], xylazine [4 mg/kg], and butorphanol [0.2 mg/kg {0.09 mg/lb}]); and KDB (ketamine [8 mg/kg {3.63 mg/lb}], detomidine [0.18 mg/kg], and butorphanol [0.3 mg/kg {0.14 mg/lb}]). A 7-day washout period was provided between treatments. At 45 minutes of anesthesia, pigs received tolazoline (2 mg/kg [0.9 mg/lb], IM; n = 6) treatment or control (5) treatment with saline (0.9% NaCl) solution.
All anesthetic combinations induced anesthesia. Endotracheal intubation was completed within 5 minutes after anesthetic administration in all pigs, except in 2 pigs following administration of KDB. Durations (mean ± SD) of endotracheal intubation and lateral recumbency in pigs that did not receive tolazoline were 55.3 ± 4.8 minutes, 83.8 ± 15.8 minutes, and 28.2 ± 4.5 minutes and 112.4 ± 18.7 minutes, 117.2 ± 16.7 minutes, and 79.7 ± 6.0 minutes, respectively, for the TZDB, TZXB, and KDB anesthetic treatments. Tolazoline significantly shortened the duration of anesthetic recovery for all anesthetic treatments without affecting the recovery quality.
All 3 anesthetic combinations were suitable for providing anesthesia in pigs. Tolazoline administration shortened the duration of anesthetic recovery without affecting the quality of recovery.
评价和比较替来他明-唑拉西泮-地托咪定-丁丙诺啡（TZDB）、替来他明-唑拉西泮-二甲苯胺噻嗪-丁丙诺啡（TZXB）和氯胺酮-地托咪定-丁丙诺啡（KDB）在猪中的麻醉、镇痛和心肺作用，并评估作为逆转剂的托拉唑啉给药后麻醉恢复时间和质量。
11 只健康的 2.5 月龄去势雄性长白混合品种猪。
在一项随机、双盲交叉研究设计中，猪接受以下 IM 麻醉组合：TZDB（替来他明-唑拉西泮[3 毫克/千克{1.36 毫克/磅}]、地托咪定[0.18 毫克/千克{0.08 毫克/磅}]和丁丙诺啡[0.12 毫克/千克{0.05 毫克/磅}]）；TZXB（替来他明-唑拉西泮[4 毫克/千克{1.8 毫克/磅}]、二甲苯胺噻嗪[4 毫克/千克]和丁丙诺啡[0.2 毫克/千克{0.09 毫克/磅}]）和 KDB（氯胺酮[8 毫克/千克{3.63 毫克/磅}]、地托咪定[0.18 毫克/千克]和丁丙诺啡[0.3 毫克/千克{0.14 毫克/磅}）。每种治疗之间有 7 天的洗脱期。在麻醉 45 分钟时，猪接受托拉唑啉（2 毫克/千克[0.9 毫克/磅]，IM；n=6）治疗或对照（5）用生理盐水（0.9%NaCl）溶液治疗。
所有麻醉组合均诱导麻醉。除了 KDB 给药后 2 只猪外，所有猪在麻醉后 5 分钟内均完成了气管内插管。未接受托拉唑啉的猪的气管内插管和侧卧时间分别为 55.3±4.8 分钟、83.8±15.8 分钟和 28.2±4.5 分钟，112.4±18.7 分钟、117.2±16.7 分钟和 79.7±6.0 分钟，分别为 TZDB、TZXB 和 KDB 麻醉处理。托拉唑啉显著缩短了所有麻醉处理的麻醉恢复时间，而不影响恢复质量。
所有 3 种麻醉组合均适用于提供猪的麻醉。托拉唑啉的给药缩短了麻醉恢复时间，而不影响恢复质量。
