局部5-氨基酮戊酸光动力疗法诱导的红斑特征
The characteristics of erythema induced by topical 5-aminolaevulinic acid photodynamic therapy.
作者信息
Clark Colin, Dawe Robert S, Moseley Harry, Ferguson James, Ibbotson Sally H
机构信息
Photobiology Unit, Department of Dermatology, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland.
出版信息
Photodermatol Photoimmunol Photomed. 2004 Apr;20(2):105-7. doi: 10.1111/j.1600-0781.2004.00085.x.
BACKGROUND
Topical photodynamic therapy (PDT) is increasingly used to treat superficial non-melanoma skin cancers. Knowledge of the characteristics of 5-aminolaevulinic acid (ALA)-induced phototoxicity will increase our understanding of PDT and may facilitate optimisation of treatment regimes.
METHODS
We examined the characteristics of ALA-induced erythema in 10 healthy subjects and investigated the effect of light source and body site.
RESULTS AND CONCLUSIONS
Maximal erythema occurred within 1-2 h of PDT and inter-individual variation in ALA-induced phototoxicity was seen. No detectable differences were seen in the phototoxicity on back or leg sites or between coherent and non-coherent light sources. These data provide further information to allow us to optimise topical PDT regimes.
背景
局部光动力疗法（PDT）越来越多地用于治疗浅表性非黑素瘤皮肤癌。了解5-氨基酮戊酸（ALA）诱导的光毒性特征将增进我们对PDT的理解，并可能有助于优化治疗方案。
方法
我们在10名健康受试者中研究了ALA诱导的红斑特征，并调查了光源和身体部位的影响。
结果与结论
PDT后1-2小时内出现最大红斑，且观察到ALA诱导的光毒性存在个体差异。背部或腿部部位的光毒性以及相干光源和非相干光源之间均未发现可检测到的差异。这些数据提供了更多信息，使我们能够优化局部PDT方案。
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