Peck Angela J, Newbern E Claire, Feikin Daniel R, Issakbaeva Elmira T, Park Benjamin J, Fehr Jason, LaMonte Ashley C, Le Thong P, Burger Terry L, Rhodes Luther V, Weltman Andre, Erdman Dean, Ksiazek Thomas G, Lingappa Jairam R
National Center for Infectious Diseases, Division of Viral and Rickettsial Diseases, Respiratory and Enteric Virus Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Emerg Infect Dis. 2004 Feb;10(2):217-24. doi: 10.3201/eid1002.030746.
In early April 2003, severe acute respiratory syndrome (SARS) was diagnosed in a Pennsylvania resident after his exposure to persons with SARS in Toronto, Canada. To identify contacts of the case-patient and evaluate the risk for SARS transmission, a detailed epidemiologic investigation was performed. On the basis of this investigation, 26 persons (17 healthcare workers, 4 household contacts, and 5 others) were identified as having had close contact with this case-patient before infection-control practices were implemented. Laboratory evaluation of clinical specimens showed no evidence of transmission of SARS-associated coronavirus (SARS-CoV) infection to any close contact of this patient. This investigation documents that, under certain circumstances, SARS-CoV is not readily transmitted to close contacts, despite ample unprotected exposures. Improving the understanding of risk factors for transmission will help focus public health control measures.
2003年4月初，一名宾夕法尼亚州居民在接触了加拿大多伦多的非典患者后被诊断感染严重急性呼吸综合征（SARS）。为确定该病例患者的接触者并评估SARS传播风险，开展了详细的流行病学调查。基于此项调查，在实施感染控制措施之前，确定有26人（17名医护人员、4名家庭接触者和5名其他人员）与该病例患者有过密切接触。临床标本的实验室检测未发现SARS相关冠状病毒（SARS-CoV）感染传播给该患者任何密切接触者的证据。此项调查证明，在某些情况下，尽管有大量无防护接触，SARS-CoV仍不易传播给密切接触者。加深对传播风险因素的了解将有助于集中采取公共卫生控制措施。
