Chung Chong Fai, Liang Chan Chung, Lai Jimmy S M, Lo Ernie S F, Lam Dennis S C
Department of Ophthalmology, United Christian Hospital, Hong Kong SAR, China.
J Cataract Refract Surg. 2005 May;31(5):938-42. doi: 10.1016/j.jcrs.2004.12.046.
To evaluate the safety of trypan blue 1% and indocyanine green (ICG) 0.5% in assisting visualization of anterior capsule during phacoemulsification in mature cataract.
Department of Ophthalmology, United Christian Hospital, Hong Kong, China.
This prospective randomized clinical trial comprised 46 eyes with mature cataract receiving phacoemulsification and posterior chamber intraocular lens implantation. They were randomized into 3 groups (trypan blue, ICG, and control without stain). Visual acuity, endothelial cell count, corneal clarity, anterior chamber reaction, and intraocular pressure (IOP) were documented before surgery and 1 week, 1 month, and 3 months postoperatively. The absolute phaco time was also recorded.
There was no significant difference in absolute phaco time (P=.17), mean endothelial cell loss (P=.72 at 1 week, P=.43 at 1 month, and P=.60 at 3 months) and no significant correlation between the absolute phaco time and the change in endothelial cell count (P=.50 at 1 week, P=.10 at 1 month, and P=.60 at 3 months) in the 3 groups. None of the patients had postoperative IOP greater than 21 mm Hg. All eyes had clear corneas and a quiet anterior chamber 3 months after surgery.
Both trypan blue 1% and ICG 0.5% are safe for assisting visualization of the anterior capsule during phacoemulsification of mature cataract.
评估1%台盼蓝和0.5%吲哚菁绿（ICG）在成熟白内障超声乳化术中辅助观察前囊膜的安全性。
中国香港联合医院眼科。
这项前瞻性随机临床试验纳入了46例接受超声乳化白内障吸除术和后房型人工晶状体植入术的成熟白内障患者。他们被随机分为3组（台盼蓝组、ICG组和未染色对照组）。记录术前及术后1周、1个月和3个月时的视力、内皮细胞计数、角膜清晰度、前房反应和眼压（IOP）。还记录了绝对超声乳化时间。
3组患者的绝对超声乳化时间（P = 0.17）、平均内皮细胞损失（1周时P = 0.72，1个月时P = 0.43，3个月时P = 0.60）无显著差异，绝对超声乳化时间与内皮细胞计数变化之间无显著相关性（1周时P = 0.50，1个月时P = 0.10，3个月时P = 0.60）。所有患者术后眼压均未超过21 mmHg。术后3个月时，所有术眼角膜均保持透明，前房安静。
1%台盼蓝和0.5%ICG在成熟白内障超声乳化术中辅助观察前囊膜均是安全的。
