Allen Theresa M, Cullis Pieter R
Department of Pharmacology, University of Alberta, Edmonton T6G 2H7, Canada.
Science. 2004 Mar 19;303(5665):1818-22. doi: 10.1126/science.1095833.
Drug delivery systems (DDS) such as lipid- or polymer-based nanoparticles can be designed to improve the pharmacological and therapeutic properties of drugs administered parenterally. Many of the early problems that hindered the clinical applications of particulate DDS have been overcome, with several DDS formulations of anticancer and antifungal drugs now approved for clinical use. Furthermore, there is considerable interest in exploiting the advantages of DDS for in vivo delivery of new drugs derived from proteomics or genomics research and for their use in ligand-targeted therapeutics.
基于脂质或聚合物的纳米颗粒等药物递送系统（DDS）的设计目的在于改善经肠胃外给药的药物的药理学和治疗特性。许多早期阻碍颗粒状DDS临床应用的问题已得到克服，目前已有几种抗癌和抗真菌药物的DDS制剂获批用于临床。此外，人们对利用DDS的优势来实现蛋白质组学或基因组学研究中获得的新药的体内递送及其在配体靶向治疗中的应用抱有浓厚兴趣。
