Clarke Daniel, Ali Mohammed A, Clifford Anthony A, Parratt Andrew, Rose Paul, Schwinn Dominik, Bannwarth Willi, Rayner Christopher M
Department of Chemistry, University of Leeds, Leeds, LS2 9JT, UK.
Curr Top Med Chem. 2004;4(7):729-71. doi: 10.2174/1568026043451096.
This review provides an introduction to three of the most well-developed solvent replacement strategies currently under investigation for synthetic chemistry: Ionic liquids, fluorous phase techniques, and supercritical carbon dioxide. They are all fascinating reaction media, and have considerable potential for use in pharmaceutical synthesis. However, this has to be balanced with problems and limitations of the new methods. This review aims to provide an overall account of recent advances in the use of unusual media for synthetic chemistry, with an emphasis on highlighting potential benefits, but also limitations, of each of the methods described.
离子液体、氟相技术和超临界二氧化碳。它们都是引人入胜的反应介质，在药物合成中具有相当大的应用潜力。然而，这必须与新方法的问题和局限性相权衡。本综述旨在全面介绍合成化学中使用非常规介质的最新进展，重点突出所描述的每种方法的潜在益处和局限性。
