Wong M L, Chia K S, Yam W M, Teodoro G R, Lau K W
Department of Community, Occupational and Family Medicine, Faculty of Medicine, National University of Singapore, Singapore.
Clin Genet. 2004 Jan;65(1):45-51. doi: 10.1111/j..2004.00192.x.
Studies on the public's willingness to donate blood specimens for genetic research are few and are conducted mainly among Western countries. Little is known about the Asian community's willingness to participate in genetic research. A community-based survey was conducted on 548 adult Singaporeans to examine their willingness to donate blood samples for genetic research and its associated factors. The response rate was 70.3%. About 49.3% (95% CI, 45.1-53.5%) were willing to donate blood for genetic research. In the multivariable Cox regression analysis, willingness was significantly associated with belief in the benefits of genetic research; intention to participate in government studies; having no fear of pain, blood, injections, and needles; and non-concern about the loss of confidentiality. Reasons against donating blood were fear of pain, blood, injections, and needles (38.1%); no self-benefits (24.8%); fear of finding out about having a disease (22.3%); fear of discrimination (18.7%); and concerns about weakness (15.1%) and weight gain (9.4%). Public education programs to promote participation in genetic research should stress its benefits and address people's fears and concerns.
关于公众为基因研究捐献血样意愿的研究较少，且主要在西方国家开展。对于亚洲人群参与基因研究的意愿了解甚少。对548名成年新加坡人进行了一项基于社区的调查，以考察他们为基因研究捐献血样的意愿及其相关因素。应答率为70.3%。约49.3%（95%可信区间，45.1 - 53.5%）愿意为基因研究献血。在多变量Cox回归分析中，意愿与对基因研究益处的信念、参与政府研究的意愿、不害怕疼痛、血液、注射和针头以及不担心保密性丧失显著相关。反对献血的原因包括害怕疼痛、血液、注射和针头（38.1%）；无自身益处（24.8%）；害怕查出患有疾病（22.3%）；害怕受到歧视（18.7%）；以及担心身体虚弱（15.1%）和体重增加（9.4%）。促进参与基因研究的公众教育项目应强调其益处，并解决人们的恐惧和担忧。
