Gilbert Saul S, van den Heuvel Cameron J, Ferguson Sally A, Dawson Drew
Centre for Sleep Research, Level 5, The Basil Hetzel Institute, University of South Australia, The Queen Elizabeth Hospital, Woodville Road, Woodville, SA 5011, Australia.
Sleep Med Rev. 2004 Apr;8(2):81-93. doi: 10.1016/S1087-0792(03)00023-6.
Temperature and sleep are interrelated processes. Under normal environmental conditions, the rhythms of core body temperature Tc and sleep propensity vary inversely across the day and night in healthy young adults. Although this relationship has drawn considerable interest, particularly in recent years, it is still not known whether this relationship is causative or merely coincidental. As somnogenic brain areas contain thermosensitive cells, it is possible that the sleep/wake cycle may be directly affected by thermoregulatory changes themselves. That is, that changes in temperature may trigger, either directly or indirectly, somnogenic brain areas to initiate sleep. There is now an emerging body of evidence from both physiological and neuroanatomical studies to indicate that this may indeed be the case. This paper will examine the literature relating to this relationship and propose a model where thermoregulatory changes provide an additional signal to the brain regions that regulate sleep and wakefulness. The model attempts to explain how temperature changes before and after sleep onset act in a positive feedback loop to maintain a consolidated sleep bout.
体温与睡眠是相互关联的过程。在正常环境条件下，健康年轻成年人的核心体温（Tc）节律和睡眠倾向在昼夜之间呈相反变化。尽管这种关系已引起了相当大的关注，尤其是近年来，但这种关系是因果关系还是仅仅是巧合仍不清楚。由于促眠脑区含有热敏细胞，睡眠/觉醒周期有可能直接受到体温调节变化本身的影响。也就是说，温度变化可能直接或间接地触发促眠脑区启动睡眠。现在，来自生理和神经解剖学研究的新证据表明情况可能确实如此。本文将审视与这种关系相关的文献，并提出一个模型，其中体温调节变化为调节睡眠和觉醒的脑区提供额外信号。该模型试图解释睡眠开始前后的温度变化如何在正反馈回路中起作用以维持一段巩固的睡眠。
