Dias P, Kumar P, Marsden H B, Gattamaneni H R, Kumar S
Christie Hospital, Manchester, United Kingdom.
Anticancer Res. 1992 Jul-Aug;12(4):1173-7.
A study of DNA content by flow cytometry revealed a significant difference between rhabdomyosarcomas, which were mainly non-diploid, and other sarcomas of children which were mainly diploid (p = 0.01). There was no association between DNA ploidy and survival or aggressive behaviour of the tumour as indicated for example by advanced clinical stage or unfavourable histology. While DNA ploidy correlated with age, it did not correlate with any other clinical characteristic. The apparent lack of prognostic value of DNA content may have been masked by some high CV values and overridden by the effect of chemotherapy which was the most significant variable in determining a patient's survival (p = 0.00005).
一项通过流式细胞术对DNA含量进行的研究显示，横纹肌肉瘤（主要为非二倍体）与儿童的其他肉瘤（主要为二倍体）之间存在显著差异（p = 0.01）。DNA倍性与肿瘤的生存率或侵袭性行为之间没有关联，例如晚期临床分期或不良组织学表现所表明的那样。虽然DNA倍性与年龄相关，但与任何其他临床特征均无关联。DNA含量明显缺乏预后价值，可能已被一些高变异系数值所掩盖，并且被化疗的影响所覆盖，化疗是决定患者生存率的最显著变量（p = 0.00005）。
