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采用两种方法对新型链阳菌素RP 59500进行体外抗葡萄球菌活性及测试。

In vitro antistaphylococcal activity and testing of RP 59500, a new streptogramin, by two methods.

作者信息

Aldridge K E, Schiro D D, Varner L M

机构信息

Louisiana State University Medical Center, New Orleans 70112.

出版信息

Antimicrob Agents Chemother. 1992 Apr;36(4):854-5. doi: 10.1128/AAC.36.4.854.

DOI:10.1128/AAC.36.4.854
PMID:1503448
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC189457/
Abstract

The in vitro antistaphylococcal activity of RP 59500, a new streptogramin, was comparable to those of vancomycin and teicoplanin against Staphylococcus aureus, and RP 59500 was the most active agent against coagulase-negative staphylococci. All staphylococcal strains were inhibited by 4 micrograms of RP 59500 per ml, including multiply resistant strains. Broth microdilution and agar dilution testing gave comparable results in 97% of the tests with RP 59500.

摘要

新型链阳菌素RP 59500对金黄色葡萄球菌的体外抗葡萄球菌活性与万古霉素和替考拉宁相当，且RP 59500是针对凝固酶阴性葡萄球菌活性最强的药物。所有葡萄球菌菌株均被每毫升4微克的RP 59500抑制，包括多重耐药菌株。在97%的RP 59500测试中，肉汤微量稀释法和琼脂稀释法给出了相当的结果。

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本文引用的文献

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In vitro activity of RP 59500, a semisynthetic injectable pristinamycin, against staphylococci, streptococci, and enterococci.半合成注射用普那霉素RP 59500对葡萄球菌、链球菌和肠球菌的体外活性
Antimicrob Agents Chemother. 1991 Mar;35(3):553-9. doi: 10.1128/AAC.35.3.553.