Vega De Céniga M, Valdés F, Aller M A, Nava M P, Chivato T, Arias J
Vascular Surgery Service, Hospital Clínico San Carlos, Madrid, Spain.
Inflammopharmacology. 2003;11(3):211-22. doi: 10.1163/156856003322315569.
Major portal pressure increase occurs on the second day post-stenosing-ligation of the portal vein in the rat and it is associated with pancreatic edema, intraperitoneal free exudate, hypoalbuminemia and hypoproteinemia. All this suggests the development of a regional exudative inflammatory response. In order to verify this hypothesis the steroid budesonide, whose antiinflammatory activity could prevent these alterations, was administered to rats with prehepatic portal hypertension. Wistar male rats were divided into the following groups: Control rats that were administered saline solution (CS; n = 10), Control rats that were administered budesonide (36 mg/kg per day; CB; n = 10), triple stenosing ligation of portal vein (TSLP) with saline solution (n = 10) and triple stenosing ligation of portal vein with budesonide (36 mg/kg per day; n = 10). In rats with prehepatic portal hypertension at 48 h of postoperative evolution, budesonide decreases the incidence of pancreatic edema, of peritoneal free exudate, of mesenteric adenopathies and prevents hypoproteinemia, hypoalbuminemia and hyper-beta-globulinemia. Some of the macroscopic intra-abdominal alterations and some of the changes in the electrophoretic pattern found in portal hypertensive rats could have an inflammatory etiopathogeny because budesonide shows an effective prophylaxis.
大鼠门静脉狭窄结扎术后第二天门静脉压力显著升高，且伴有胰腺水肿、腹腔游离渗出液、低白蛋白血症和低蛋白血症。所有这些都提示出现了局部渗出性炎症反应。为了验证这一假说，将具有抗炎活性、可预防这些改变的类固醇布地奈德给予肝前性门静脉高压大鼠。将雄性Wistar大鼠分为以下几组：给予盐溶液的对照大鼠（CS；n = 10）、给予布地奈德（36 mg/kg/天）的对照大鼠（CB；n = 10）、接受门静脉三重狭窄结扎并给予盐溶液的大鼠（n = 10）以及接受门静脉三重狭窄结扎并给予布地奈德（36 mg/kg/天）的大鼠（n = 10）。在肝前性门静脉高压大鼠术后48小时的病程中，布地奈德可降低胰腺水肿、腹腔游离渗出液、肠系膜淋巴结病的发生率，并预防低蛋白血症、低白蛋白血症和高β球蛋白血症。门静脉高压大鼠出现的一些腹部宏观改变以及电泳图谱中的一些变化可能具有炎症病因，因为布地奈德显示出有效的预防作用。
