Monterde G, Rodríguez-Fabian G, Vara E, López L, Arias J, Aller M A, Arias J
Surgery Department and Biochemical, Faculty of Medicine, Complutense University, Madrid, Spain.
Dig Dis Sci. 2000 Sep;45(9):1865-71. doi: 10.1023/a:1005588918516.
Corticosterone, T3, T4, and prolactin serum concentrations at 24 hr (N = 10), 15 days (N = 10), and 45 days (N = 10) of postoperative (postop) evolution were assayed to study the neuroendocrine response to portal hypertension. A triple stenosing ligature of the portal vein was used as the surgical technique of portal hypertension. This technique does not produce mortality and causes a decrease in the serum concentrations of T3 (0.043 +/- 0.009 vs 0.55 +/- 0.08 ng/ml) and T4 (3.93 +/- 0.55 vs 4.65 +/- 0.67 microg/ml) and an increase in those of prolactin (28.61 +/- 20.20 vs 12.84 +/- 3.96 ng/ml) and corticosterone (397.50 +/- 64.17 vs 311.53 +/- 57.41 ng/ml) at 45 days postop. The T3, T4, prolactin, and corticosterone alterations are associated with a persistent increase of TNF-alpha and NO, whose serum concentrations at 45 days postop are, respectively, 1838.33 +/- 247.07 vs 48.89 +/- 8.75 pg/ml and 0.43 +/- 0.13 vs 0.19 +/- 0.01 mmol/ml. TNF-alpha and NO could mediate these hormonal alterations in the evolution of short-term portal hypertension in the rat; thus they are involved in the systemic neuroendocrine response that is induced by this injury.
在术后24小时（n = 10）、15天（n = 10）和45天（n = 10）时测定血清皮质酮、T3、T4和催乳素浓度，以研究对门静脉高压的神经内分泌反应。采用门静脉三联狭窄结扎术作为门静脉高压的手术技术。该技术不会导致死亡，并导致术后45天时T3（0.043±0.009对0.55±0.08 ng/ml）和T4（3.93±0.55对4.65±0.67μg/ml）的血清浓度降低，催乳素（28.61±20.20对12.84±3.96 ng/ml）和皮质酮（397.50±64.17对311.53±57.41 ng/ml）的血清浓度升高。T3、T4、催乳素和皮质酮的改变与TNF-α和NO的持续升高有关，术后45天时它们的血清浓度分别为1838.33±247.07对48.89±8.75 pg/ml和0.43±0.13对0.19±0.01 mmol/ml。TNF-α和NO可能在大鼠短期门静脉高压的演变中介导这些激素变化；因此，它们参与了由这种损伤诱导的全身神经内分泌反应。
