Glasgow Russell E
Clinical Research Unit, Kaiser Permanente Colorado, 335 Roadrunner Lane, Penrose, CO 81240, USA.
Curr Diab Rep. 2004 Apr;4(2):111-2. doi: 10.1007/s11892-004-0065-x.
There is a well-documented gap between research and practice in diabetes and many other chronic illnesses. This gap is due, in part, to limitations of the research database. Different types of clinical trials have recently been called for that address issues central to clinicians, administrative decision makers, and policy makers. Such "practical clinical trials" that are conducted in multiple heterogeneous settings offer great potential. They include diverse patient populations, study clinically relevant and feasible interventions, and assess multiple outcomes. In this article, examples of these trials are provided, and design features that will facilitate clinical and policy decision making are summarized.
在糖尿病及许多其他慢性疾病的研究与实践之间，存在着一个有充分文献记载的差距。造成这一差距的部分原因是研究数据库的局限性。最近人们呼吁开展不同类型的临床试验，以解决临床医生、行政决策者和政策制定者所关注的核心问题。在多个不同环境中进行的此类“实用临床试验”具有巨大潜力。它们纳入了不同的患者群体，研究临床相关且可行的干预措施，并评估多种结果。本文提供了这些试验的实例，并总结了有助于临床和政策决策的设计特点。
