Glasgow Russell E, Davidson Karina W, Dobkin Patricia L, Ockene Judith, Spring Bonnie
Kaiser Permanente, Penrose, Colorado, USA.
Ann Behav Med. 2006 Feb;31(1):5-13. doi: 10.1207/s15324796abm3101_3.
There is a well-documented gap between research and practice in many areas of behavioral medicine. This gap is due in part to limitations in the capacity of the research database to address questions that are of central concern to clinicians, administrative decision makers, and policymakers. Thus, there has been a call for "practical clinical trials" that compare clinically viable alternative interventions and assess multiple outcomes important for clinical and policy decisions in diverse patient populations and settings. Such trials offer great potential, and they raise interesting challenges regarding optimal research design and source of funding. We discuss issues related to practical clinical trials in behavioral medicine, propose a need for practical behavioral trials (PBTs), and describe design features that will facilitate clinical and policy decision making. This type of PBT can help to close the gap between research and practice and advance the field of evidence-based behavioral medicine. We discuss potential challenges and objections to PBTs and conclude by providing recommendations for the design, conduct, reporting, and review of practical trials.
行为医学的许多领域在研究与实践之间存在着有据可查的差距。这种差距部分归因于研究数据库在解决临床医生、行政决策者和政策制定者核心关注问题方面的能力限制。因此，人们呼吁开展“实用临床试验”，比较临床上可行的替代干预措施，并评估对不同患者群体和环境中的临床及政策决策至关重要的多种结果。此类试验具有巨大潜力，同时也在最佳研究设计和资金来源方面提出了有趣的挑战。我们讨论了行为医学中与实用临床试验相关的问题，提出了开展实用行为试验（PBT）的必要性，并描述了有助于临床和政策决策的设计特征。这种类型的PBT有助于弥合研究与实践之间的差距，并推动循证行为医学领域的发展。我们讨论了对PBT的潜在挑战和反对意见，并通过为实用试验的设计、实施、报告和审查提供建议来得出结论。
